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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome. It is one of a small class of "mitochondrial-derived peptides" (MDPs) identified as signaling molecules that communicate between mitochondria and the nucleus, and has become a focus of research into metabolic regulation and cellular aging.
Proposed mechanisms of action:
Activates AMPK (AMP-activated protein kinase), a central regulator of cellular energy metabolism
Promotes glucose uptake and utilization independent of insulin signaling
Regulates gene expression via the "mitochondrial-nuclear communication" pathway, including translocation to the nucleus under metabolic stress
Influences fatty acid oxidation and metabolic homeostasis
Studied for potential roles in counteracting age-related and diet-induced insulin resistance
Research applications include:
Metabolic syndrome and insulin resistance studies
Exercise physiology and metabolic adaptation research
Aging and longevity-related pathway studies
Obesity and energy balance models
Mitochondrial function and cellular stress response research
Molecular characteristics:
16-amino acid peptide
Derived from the mitochondrial 12S rRNA gene region
Endogenously produced, with levels shown to decline with age in some studies
Water-soluble, typically supplied as a lyophilized powder for reconstitution
Important: This product is intended strictly for in-vitro laboratory research use only. It is not for human or animal consumption, and is not a drug, food, or cosmetic. Not evaluated for safety, efficacy, or purity for clinical use. Handle only in a controlled research environment by qualified personnel.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome. It is one of a small class of "mitochondrial-derived peptides" (MDPs) identified as signaling molecules that communicate between mitochondria and the nucleus, and has become a focus of research into metabolic regulation and cellular aging.
Proposed mechanisms of action:
Activates AMPK (AMP-activated protein kinase), a central regulator of cellular energy metabolism
Promotes glucose uptake and utilization independent of insulin signaling
Regulates gene expression via the "mitochondrial-nuclear communication" pathway, including translocation to the nucleus under metabolic stress
Influences fatty acid oxidation and metabolic homeostasis
Studied for potential roles in counteracting age-related and diet-induced insulin resistance
Research applications include:
Metabolic syndrome and insulin resistance studies
Exercise physiology and metabolic adaptation research
Aging and longevity-related pathway studies
Obesity and energy balance models
Mitochondrial function and cellular stress response research
Molecular characteristics:
16-amino acid peptide
Derived from the mitochondrial 12S rRNA gene region
Endogenously produced, with levels shown to decline with age in some studies
Water-soluble, typically supplied as a lyophilized powder for reconstitution
Important: This product is intended strictly for in-vitro laboratory research use only. It is not for human or animal consumption, and is not a drug, food, or cosmetic. Not evaluated for safety, efficacy, or purity for clinical use. Handle only in a controlled research environment by qualified personnel.